Kris Jenner has revealed that her attempt to use Ozempic for weight loss left her extremely unwell before she switched to peptide injections that she now calls life changing.
The Kardashians matriarch, 70, opened up about her experience during an appearance on the SHE MD podcast, explaining she used the medication well before it became a widespread Hollywood trend.
She recalled that after trying the drug, she quickly experienced severe side effects. “I did not do, like, an Ozempic. I tried it. We tried it once when no one knew what it was and it made me really sick,” she admitted.
The symptoms were so strong that Jenner said she could barely function. “I can’t work anymore. I can’t. I’m so sick. I can’t, like nauseous,” she recalled, adding that her reaction forced her to stop treatment.
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According to Jenner, her doctor immediately took her off the medication and began searching for alternatives that would be safer for her. “She goes: ‘Okay, okay. Let’s try something else’ … [We] dialed around and looked at different options,” Kris said.
After testing different methods, Jenner discovered a regimen that worked better for her, involving peptide injections combined with nutritional supplements.
She described the change as a major turning point in how she felt day to day. “I realized that a peptide injection was really great for me. And then I follow it up with supplements. And that was a game changer,” she said.
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Jenner also mentioned that the new plan improved her energy levels and allowed her to be more productive.
She said the peptides gave her “an extra couple hours at night” since she no longer experienced the evening exhaustion that had become so common before.
In addition to her new routine, Jenner opened up about her physical transformation following a facelift in 2025, saying the procedure contributed to maintaining her refreshed appearance. “I had a very, well‑known facelift a year ago. So that was helpful,” she said.
Her comments followed recent speculation that she regretted the surgery — claims she was quick to deny on Khloé Kardashian’s Khloé in Wonderland podcast.
She firmly addressed the rumors, telling her daughter, “The headline right now is that I hate my facelift, and I’m really mad at — I’m furious at my doctor, Steven Levine, which couldn’t be further from the truth. It’s a flat‑out lie. I love my facelift. I adore my doctor. I’m obsessed with him.”
Jenner has spoken openly about cosmetic procedures in the past, previously telling Vogue Arabia that undergoing another facelift fifteen years after her first one felt empowering.
At the time, she explained her reasoning by saying she wanted to continue being the “best version” of herself, even as she aged.
She said, “Just because you get older, it doesn’t mean you should give up on yourself.”
Her philosophy about beauty and aging remains consistent, as she summarized, “If you feel comfortable in your skin and you want to age gracefully – meaning you don’t want to do anything – then don’t do anything. But for me, this is aging gracefully. It’s my version.”
Jenner’s latest anecdotes reflect her characteristic mix of candor and control, offering glimpses into how she balances personal health with public scrutiny while continuing to shape her own approach to wellness and appearance.
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